High ICA levels can be measured a number of
years before clinical signs of diabetes are seen, and this
test is a very helpful tool your doctor may use to prevent
the disease or to better manage the onset, as well as to provide
a proper diet and treatment. ICA testing must be done before
any insulin therapy is started, since this will cause elevations
in this antibody in the blood. ICA tests are ordered to diagnose
Type I diabetes mellitus (DM), insulin allergy, insulin resistance;
or to monitor your condition after a pancreas transplant.
are islet cells and islet cell antibodies?
cells are located in the pancreas and make hormones including
insulin, glucagon, somatomammotropin, and pancreatic polypeptide.
In some people, the immune system produces islet cell antibodies,
which attack and destroy the islet cells as though they
were foreign substances; this can lead to serious health
conditions, such as type 1 diabetes.
will the results of Islet cell antibody (ICA) test tell
cell antibodies have a prevalence of 75% in IDDM at diagnosis
i.e. about 75% people who have type I diabetes, will show
Islet cell antibodies in their blood. Similarly, Islet Cell
Antibodies are associated with a 50% risk of developing
diabetes mellitus in 5 years.
to diabetes autoantibody panel