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Diabetes Autoantibody >> ICA
Islet cell antibody (ICA)

High ICA levels can be measured a number of years before clinical signs of diabetes are seen, and this test is a very helpful tool your doctor may use to prevent the disease or to better manage the onset, as well as to provide a proper diet and treatment. ICA testing must be done before any insulin therapy is started, since this will cause elevations in this antibody in the blood. ICA tests are ordered to diagnose Type I diabetes mellitus (DM), insulin allergy, insulin resistance; or to monitor your condition after a pancreas transplant.

What are islet cells and islet cell antibodies?
Islet cells are located in the pancreas and make hormones including insulin, glucagon, somatomammotropin, and pancreatic polypeptide. In some people, the immune system produces islet cell antibodies, which attack and destroy the islet cells as though they were foreign substances; this can lead to serious health conditions, such as type 1 diabetes.

What will the results of Islet cell antibody (ICA) test tell me?
Islet cell antibodies have a prevalence of 75% in IDDM at diagnosis i.e. about 75% people who have type I diabetes, will show Islet cell antibodies in their blood. Similarly, Islet Cell Antibodies are associated with a 50% risk of developing diabetes mellitus in 5 years.

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